Histocompatibility and imprinting status of parthenogenetic embryonic stem cells.
- Author:
Yuan XUE
1
;
Zhiyan SHAN
;
Zhong ZHENG
;
Lei LEI
Author Information
1. Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Embryonic Stem Cells;
cytology;
Female;
Gene Expression Profiling;
methods;
Gene Expression Regulation, Developmental;
genetics;
physiology;
Genomic Imprinting;
Histocompatibility;
Parthenogenesis;
genetics;
physiology;
Pluripotent Stem Cells;
cytology
- From:
Journal of Biomedical Engineering
2010;27(5):1158-1161
- CountryChina
- Language:Chinese
-
Abstract:
The parthenogenetic embryonic stem cells (pESCs) derived from parthenogenetic embryos have the totipotency and proliferation capacity similar to those of the fertilized embryonic stem cells (fESCs). Therefore, the establishment of pESCs line avoids destroy of embryo and kence may make pESCs less concerns with political and ethical issues. These cells are characterized by their histocompatibility with the oocyte donor and therefore is more suitable for cell and tissue replacement therapy. In addition, because of the typical imprinting status, pESCs also provide a valuable in vitro model system for studying the molecular mechanisms in genomic imprinting.
