Advancement of studies on ALDH1 as a universal marker of stem cells.
- Author:
Mingli HAN
1
;
Chengyi WU
Author Information
1. Department of Endocrine Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biomarkers;
metabolism;
Biomarkers, Tumor;
metabolism;
Humans;
Isoenzymes;
metabolism;
Neoplastic Stem Cells;
metabolism;
Retinal Dehydrogenase;
metabolism;
Stem Cells;
metabolism
- From:
Journal of Biomedical Engineering
2010;27(5):1183-1186
- CountryChina
- Language:Chinese
-
Abstract:
Aldehyde dehydrogenase 1 (ALDH1, ALDH1A1 or RALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, was shown to have a function in the early differentiation of stem cells. Its activity shows promising potential as a universal marker for the identification and isolation of normal stem cells and cancer stem cells from multiple sources in a variety of tissue types. Herein, we review the available data reporting the utilization of ALDH1 activity as a means to identify and isolate normal stem cells and cancer stem cells (CSCs), and the potential diagnostic and therapeutic implications, with a special focus on the mammary gland and breast cancer. The research opportunity in this area of interest is emphasized.
