Synthesis, characterization and electrospinning of biodegradable polyurethanes based on poly(epsilon-caprolactone) and L-lysine diisocynate.
- Author:
Jian HAN
1
;
Lin YE
;
Aiying ZHANG
;
Zengguo FENG
Author Information
1. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemical synthesis;
chemistry;
Blood Vessel Prosthesis;
Isocyanates;
chemistry;
Lysine;
analogs & derivatives;
chemistry;
Polyesters;
chemistry;
Polyurethanes;
chemical synthesis;
chemistry;
Tissue Engineering;
methods;
Tissue Scaffolds
- From:
Journal of Biomedical Engineering
2010;27(6):1274-1279
- CountryChina
- Language:Chinese
-
Abstract:
A novel diisocyanate, i. e. lysine ethyl ester diisocyanate (LDI), was prepared by the present authors. Poly (epsilon-caprolactone) (PCL) (M(n) = 2000) was used for reacting with LDI to form prepolymer, and then the chain was extended with butanediol (BDO) to form polyurethane (PU). PU was characterized by gel permeation chromatography, FTIR and 1H-NMR. Mechanical properties test revealed that PU possesses excellent tensile strength. Hydrolytic degradation and enzymatic degradation of PU films showed that PU is biodegradable. Finally, vascular scaffold of PU was fabricated by electrospinning. Morphological and biomechanical properties of scaffold were examined. The tensile strength was 8MPa, suture retention strength 12N, porosity 75% and burst pressure strength 150-170 kPa. Cytotoxicity and cell adhesion showed that PU scaffolds are biocompatible. These results demonstrate that PU vascular scaffolds possess excellent physical strength and biocompatibility and can be developed as substitutes for native blood vessels.
