Poorly Differentiated Endometrial Adenocarcinoma with Trophoblastic Differentiation.
- Author:
Hyun Jung SONG
1
;
Sung Shin SHIM
;
Woon Sup HAN
;
Seung Cheol KIM
Author Information
1. Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Endometrial adenocarcinoma;
Trophoblastic differentiation;
tumor marker;
beta-hCG
- MeSH:
Adenocarcinoma*;
Aged;
Chorionic Gonadotropin;
Diagnosis;
Drug Therapy;
Endometrial Neoplasms;
Female;
Humans;
Liver;
Lung;
Neoplasm Metastasis;
Trophoblasts*
- From:Korean Journal of Obstetrics and Gynecology
2002;45(5):888-893
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Trophoblastic differentiation in gynecologic nontrophoblastic tumor is very rare. Here we present a 66-year-old female with poorly differentiated endometrial carcinoma showing trophoblast-like differentiation. This tumor was in advanced stage with metastases to lung, liver, and bone at diagnosis. The multinucleated, syncytiotrophoblast-like cells were positive for beta-human chorionic gonadotropin (beta-hCG) by immunochemical stain. The level of beta-hCG was also elevated (219 mIU/ml) in the patient's serum, but dropped after surgery and chemotherapy. beta-hCG may be used as tumor marker in this case.
