Progress and prospect in the research of bone morphogenetic protein heterodimer.
- Author:
Yuanna ZHENG
1
;
Linhong WANG
;
Zhiyuan GU
Author Information
1. Stomatology Hospital of Zhejiang University, Hangzhou 310006, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biopolymers;
Bone Morphogenetic Protein 2;
Bone Morphogenetic Protein 7;
Bone Morphogenetic Proteins;
genetics;
pharmacology;
Humans;
Protein Multimerization
- From:
Journal of Biomedical Engineering
2010;27(6):1428-1432
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic protein (BMP) homodimers are of significant osteoinductivity. However, their clinical application is limited because of high effective dosage. Recently, BMP heterodimers are reported to address the issue. This is a review of the researches on BMP heterodimers, including existent evidences, types and synthetic methods, biological activities in comparison to BMP homodimers and possible mechanisms, further research direction and future expectations.
