Mircocarriers' motion in rotating wall vessels.
- Author:
Xiao MA
1
;
Chun YANG
;
Fengyuan ZHUANG
Author Information
1. School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Cell Culture Techniques;
instrumentation;
methods;
Gravitation;
Models, Theoretical;
Motion;
Rotation;
Stress, Mechanical;
Weightlessness Simulation
- From:
Journal of Biomedical Engineering
2010;27(6):1433-1438
- CountryChina
- Language:Chinese
-
Abstract:
Rotating wall vessels (RWVS), an ingenious apparatus for three-dimensional suspension culture, is widely used to build a simulated microgravity-effect on cell. Independent researchers have proposed hypotheses to illustrate why RWVS can simulate certain aspects of microgravity. Many of the hypotheses stated that the culture condition in RWVS is determined by the cellular mechanical environment which is a result of low fluid shear and microcarrier's motion. The microcarrier's motions consist of primary and secondary motions. In the light of the analysis of forces loaded by the microcarriers, some conclusions are drawn from the data on microcarriers' primary and secondary motions about which many simulations and observations have already been conducted.
