Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice.
- Author:
Yanmeng ZHOU
1
;
Yubo LIU
;
Yunsheng GAO
Author Information
- Publication Type:Journal Article
- MeSH: Alkaline Phosphatase; blood; Animals; Bone Density; drug effects; Disease Models, Animal; Diterpenes, Abietane; Drugs, Chinese Herbal; administration & dosage; Female; Humans; Male; Mice; Osteoporosis; blood; chemically induced; drug therapy; prevention & control; Phenanthrenes; administration & dosage; Tretinoin; adverse effects
- From: China Journal of Chinese Materia Medica 2010;35(21):2923-2926
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the prevention and therapeutic effects of tanshitone (TAN) on retinoic acid induced osteoporosis in mice.
METHODThe mice osteoporosis was induced by given retinoic acid intragastrically for two weeks. The histomorphological features of bone were observed and biochemical indexes in serum (Ca, P, ALP, TRAP, E2, BGP) were determined after the mice were given TAN at the dose of 40, 80, 160 mg x kg(-1) respectly.
RESULTTanshinone can induce high conversion of osteoporosis. The levels of P, ALP, TRAP and BGP in the TAN groups were lower than the model group, while the E2 level was higher than the model group.
CONCLUSIONTanshitone can prevent the loss bone in the experimental mice. The mechanism may be that it improves the level of estrogenic hormone and inhibits the high bone turnover.
