Effect of three penetration enhancers on corneal permeability of mangiferin in vitro.
- Author:
Rui LIU
1
;
Zhidong LIU
;
Lexin SHU
;
Chengui ZHANG
;
Boli ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cornea; drug effects; metabolism; Drug Carriers; chemistry; Ethylene Glycols; chemistry; Glycerides; In Vitro Techniques; Organic Chemicals; chemistry; Permeability; Plant Extracts; pharmacokinetics; Polyethylene Glycols; chemistry; Rabbits; Stearic Acids; chemistry; Xanthones; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2010;35(23):3131-3135
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of labrasol, solutol HS 15 and transcutol P on the corneal permeability of mangiferin in vitro.
METHODThe effects of three penetration enhancers on the corneal permeability of mangiferin were investigated in vitro by using isolated rabbit corneas.
RESULTThe apparent Papp enhancements were increased 1.80, 3.27, 3.41 and 4.76-folds with Lab at 1.0%, 1.5%, 2.0% and 3.0% (P < 0.01), respectively. The apparent Papp increased 1.98 and 3.07-folds with Sol at 0.2% and 0.4% (P < 0.01), respectively, but reduced with 0.010%-0.03% Trans.
CONCLUSIONThe Papp value of mangiferin is significantly enhanced by 1.0%-3.0% Lab, 0.2% and 0.4% Sol, however the Papp value of mangiferin is reduced by 0.01%-0.03% Trans.
