Serum metabolome analysis reveals effect of panax notoginosides on ischemic rat after acute myocardial infarction.
- Author:
Jin WANG
1
;
Yufeng ZHANG
;
Qing SHAO
;
Xiaohui FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; therapeutic use; Humans; Male; Metabolome; Myocardial Infarction; drug therapy; metabolism; Myocardial Ischemia; drug therapy; metabolism; Panax; chemistry; Rats; Rats, Sprague-Dawley; Serum; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(23):3199-3202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe effect of panax notoginosides on ischemic rat after acute myocardial infarction by coronary artery ligation was preliminarily investigated using metabonomics approach.
METHODGC-MS based metabonomics approach was applied to analyse the serum metabolome of normal group, model group and treatment group of rats. Furthermore, PCA and PIS-DA was used to identify the differentially expressed metabolites among the three groups.
RESULTA good fit and prediction results using metabolome data was obtained by PCA and PL-DA. Moreover, 10 metabolites were selected as potential biomarkers for efficacy evaluation of panax notoginosides by t-test and variable importance in the projection.
CONCLUSIONMetabonomics provides a whole-organism biological description of pathological or physiological state, and likely can be used as a new approach for efficacy evaluation of traditional Chinese medicine.
