Influence of suoquan capsule on detrusor of D-galactose mimetic rats.
- Author:
Ying TAN
1
;
Ping HUANG
;
Hongying CAO
;
Meng SHI
;
Qinghe WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; Female; Galactose; adverse effects; Humans; Male; Muscle Contraction; Muscle, Smooth; physiology; Rats; Urinary Bladder; drug effects; metabolism; physiopathology; Urinary Incontinence, Urge; chemically induced; drug therapy; metabolism; physiopathology; Urination; drug effects
- From: China Journal of Chinese Materia Medica 2010;35(23):3207-3210
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss the influence of Suoquan capsule (SQJN) on the detrusor of D-galactose mimetic rats, and to explore the mechanism of reducing urine.
METHODInvestigate the enzymes (ATPase, SDH, SOD, MDA, Na+ -K+ -ATPase, Ca2+ - Mg2+ -ATPase) which influence the production and excretion of urine and the reactivity of urinary detrusor strips to different concentrations of ISO and ATP.
RESULTCompared with the model group, the activity of SOD, Na+ -K+ -ATPase, Ca2+ -Mg2+ -ATPase and SDH increased significantly in aging rats after administrating SQJN (P < 0.01); the complaisance and elasticity of bladder also increased (P < 0.05). The frequency of spontaneous contraction and the MDA decreased significantly (P < 0.05-0.01). The decreased relaxation response to ISO and increased contractile response to ATP were also changed after administrating SQJN.
CONCLUSIONSQJN can regulate the metabolism of fluid through recovering the normal physiologic function of the detrusor of bladder.
