Inhibitory effect of baicalin on germ tube formation and adhesion of Candida albicans.
- Author:
Changzhong WANG
1
;
Xin FENG
;
Xiaolu ZHANG
;
Qian ZHU
;
Chuanqi XIE
;
Huijuan CHENG
;
Yan WANG
;
Yun YUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Anti-Infective Agents; pharmacology; Candida albicans; drug effects; growth & development; physiology; Candidiasis; drug therapy; microbiology; Cheek; microbiology; Epithelial Cells; microbiology; Female; Flavonoids; pharmacology; Humans; Mouth Mucosa; microbiology; Vagina; microbiology; Young Adult
- From: China Journal of Chinese Materia Medica 2010;35(23):3216-3218
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of baicalin against Candida albicans germ tube formation, and adherence to buccal epitherial and vaginal epitherial cells.
METHODVarious concentrations of baicalin (100, 50, 10 mg x L(-1)) were incubated with C. albicans suspension, the mixed suspension of C. albicans and human buccal epitherial cells, the mixed suspension of C. albicans and vaginal epitherial cells, respectively. The effects of baicalin on C. albicans germ tube formation, and adherence to buccal epitherial and vaginal epitherial cells were then assessed microscopically.
RESULTAll concentrations of baicalin could inhibit C. albicans germ tube formation, and adherent to buccal epitherial and vaginal epitherial cells,while there was no significant difference between standard and clinical strains.
CONCLUSIONBaicalin could inhibit C. albicans germ tube formation, and adherence to buccal epitherial and vaginal epitherial cells.
