Preparation and quality evaluation of ginkgolide B-loaded self microemulsifying drug delivery system.
- Author:
Mengxiang GUO
1
;
Haiyan HU
;
Shibo TANG
;
Xiaobo ZHU
;
Yandong WANG
;
Jianqiao LI
;
Wei MA
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; instrumentation; methods; Drug Delivery Systems; instrumentation; methods; Emulsions; chemistry; Ginkgolides; chemistry; pharmacokinetics; Lactones; chemistry; pharmacokinetics; Particle Size; Solubility; Surface-Active Agents; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(22):2967-2971
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare ginkgolide B-loaded self microemulsifying drug delivery system (SMEDDS) and evaluate its quality.
METHODThe solubility of ginkgolide B in different oil, surfactant and co-surfactant were measured by HPLC-ESI-MS. The GB-SMEDDS formulation was optimized by the self emulsifying efficiency of various combinations of oil and mix-surfactant evaluated by using pseudo-temary phase diagram. The preliminary stability of GB-SEMEDDS was evaluated by the variety of loading rate of GB and dispersed medium. The morphology, the particle size and the formulation stability were evaluated after diluting by 0.1 mol x L(-1) HCl.
RESULTThe blank self microemulsified system was composed of ethyl oleate-( cremophor EL-lecithin-ethanol, 4: 1:2) (40: 60), the loading dosage was 2.5%. Little influence of GB and emulsified medium was observed on the stability of GB-SEMDDS. After diluted with 0.1 mol x L(-1) HCl, the morphology of the microemulsion was homogeneous small spherical drops observed under electro-microscope. The particle size was (41.6 +/- 1.11) nm, the self microemulsifing time was around 2 min. The formulation was stable within 8 h, without significant changes in particle size and separation of drugs.
CONCLUSIONGB-SMEDDS is easy to prepare and its quality is stable. The solubility of GB was significantly improved by SMEDDS.
