Preparation and in vitro drug release of ferulic acid loaded chitosan microspheres containing liposomes.
- Author:
Jifen ZHANG
1
;
Qin WANG
;
Lan JIA
;
Yu ZHANG
;
Xiaoyu XU
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Chitosan; chemistry; Coumaric Acids; chemistry; pharmacokinetics; Delayed-Action Preparations; chemistry; pharmacokinetics; Drug Compounding; Kinetics; Liposomes; chemistry; Microspheres; Particle Size
- From: China Journal of Chinese Materia Medica 2010;35(22):2972-2975
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo construct the ferulic acid loaded chitosan microspheres containing liposomes.
METHODFerulic acid was selected to be the model drug. Liposomes were prepared by calcium acetate gradient method. The entrapment efficiency of liposomes was(79.97 +/- 0.54)%, the average size was (187.6 +/- 11.9) nm and the Zeta potential was -12.67 +/-1.78. The chitosan microspheres, whose entrapment efficiency was (57.89 +/- 1.72)%, were prepared by onic gelation method after liposomes were mixed with chiotosan solution. Ferulic acid was entrapped in liposomes in amorphous form and then liposomes were distributed in microspheres intactly.
RESULTThe 80.97% liposomes were released from microspheres and the 32.33% ferulic acid was released from microspheres at 12 h, which was much slower than simple chitosan microspheres.
CONCLUSIONThis study demonstrated that chitosan microspheres containing liposomes have good sustained-releasing property in vitro.
