Anti-HBV constituents from Euphorbia fischeriana.
- Author:
Meihua YU
1
;
Aijun HOU
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; analysis; isolation & purification; pharmacology; Drugs, Chinese Herbal; analysis; isolation & purification; pharmacology; Euphorbia; chemistry; Hepatitis B virus; drug effects; Plant Roots; chemistry
- From: China Journal of Chinese Materia Medica 2010;35(22):3002-3006
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the anti-HBV constituents in the roots of Euphorbia fischeriana.
METHODThe compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Some compounds were tested for the anti-HBV activity.
RESULTEleven compounds were isolated and identified as tirucalla-5,24-dien-3-ol (1), 24-methyltirucalla-5, 24-dien-3-ol (2), euphol (3), butyrospermol (4), 24-methylenecycloartenol (5), cycloartenol (6), jolkinolid E (7) helioscopinolide A (8), isoscopoletion (9), dephnoretin (10), and 3, 3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside (11).
CONCLUSIONCompounds 1, 2 and 10 were isolated from the genus Euphorbia for the first time. Compounds 3, 4 and 11 were isolated from this species for the first time. Compounds 1, 8, 9 and 11 showed weak anti-HBsAg and anti-HBeAg activity, while compound 10 showed weak anti-HBsAg activity.
