Research on phytoestrogenic effect of formononetin.
- Author:
Jie YU
1
;
Piwen ZHAO
;
Jianzhao NIU
;
Jifeng WANG
;
Yuankui CAO
;
Qingxiu HAO
Author Information
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; drug therapy; genetics; metabolism; physiopathology; Cell Line, Tumor; Cell Proliferation; drug effects; Female; Humans; Isoflavones; pharmacology; Phytoestrogens; pharmacology; Receptors, Estrogen; genetics; metabolism
- From: China Journal of Chinese Materia Medica 2010;35(22):3060-3064
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEResearch on the phytoestrogenic effect and its possible mechanism of formononetin.
METHODTo evaluate the estrogenic effect and mechanisms of formononetin through the test of its influence on proliferation and ER subtype expression of T47D cells.
RESULTThe proliferation rates of T47D cells treated with 1 x 10(-7) -1 x 10(-6) mol x L(-1) formononetin were not increased. On the influence of ICI182, 780, the proliferation rates of T47D cells treated with 1 x 10(-7) 1 x 10(-6) mol x L(-1) formononetin were decreased. Formonenetin could induce the augment of ERalpha expression significantly of T47D.
CONCLUSIONFormonenetin has phytoestrogenic effect Formonenetin can not accelerate ER(+) T47D cell proliferation. But the expression level of ERalpha subtype in T47D cells change significantly with certain concentrations of formonenetin.
