Application of quantitative fingerprint technique for in-process quality control of Guizhi Fuling capsules.
- Author:
Jiachun LI
1
;
Na LIANG
;
Wei XIAO
;
Yu'an BI
;
Zhenzhong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Capsules; Chromatography, High Pressure Liquid; methods; Drugs, Chinese Herbal; analysis; standards; Quality Control
- From: China Journal of Chinese Materia Medica 2010;35(24):3270-3273
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate an evaluation mode FOR in-process quality control for traditional Chinese medicines by adopting quantitative fingerprint technique as the main mean.
METHODRegarding Guizhi Fuling capsules as an example, the stability and repeatability were observed by tests of quantitative fingerprint of 90% ethanol extract, aqueous extract, the final mixing extract, soft material and products during the production process.
RESULTThe fingerprint similarities of four kinds of intermediates and products from 10 batches of Guizhi Fuling capsules were in the range of 0.966-0.999, respectively. The RSD of quantitative results of marked components, which included gallic acid, paeoniflorin, benzoic acid, cinnamic acid, benzoyl paeoniflorin, cinnamic aldehyde, paeonol, etc, were less than 15% in the products.
CONCLUSIONThis method is accurate, feasible and could be an effective way to be applied to in-process quality control of traditional Chinese medicine.
