Study on transdermal absorption of piperine in Erxiekang plaster.
- Author:
Yeli GAO
1
;
Jian NI
;
Xingbin YIN
;
Xiaochun SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; metabolism; Animals; Benzodioxoles; metabolism; Linear Models; Male; Piperidines; metabolism; Polyunsaturated Alkamides; metabolism; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Skin Absorption
- From: China Journal of Chinese Materia Medica 2010;35(24):3294-3296
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the absorbed character of piperine in Erxiekang plaster, and piperine by transdermal absorption was determined.
METHODThe percutaneous absorption of piperine in vitro at different times was conducted by Franz osmosis and diffusion apparatus as well as high-performance liquid chromatography.
RESULTIt showed that the piperine through skins of mice gradually increased within the experiment time. After 52 h, the penetration of piperine was 78.51%, and remained basically unchanged.
CONCLUSIONThe method is reliable, and can be used for Erxiekang plaster of determination of transdermal absorption.
