Antitumor activities of liposoluble components of caulis Marsdeniae tenocissimae and analysis on its chemical constituents.
- Author:
Hui ZHANG
1
;
Zhidong PEI
;
Xiuya ZHANG
;
Tingguo KANG
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; analysis; chemistry; pharmacology; Cell Proliferation; drug effects; Gas Chromatography-Mass Spectrometry; Hep G2 Cells; Humans; Lipids; chemistry; Marsdenia; chemistry; Solubility
- From: China Journal of Chinese Materia Medica 2010;35(24):3325-3328
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the antitumor activities of the liposoluble components from caulis Marsdenia tenocissimae and analyze its chemical constituents.
METHODThe supercritical fluid extraction was used to extract the liposoluble components from caulis M. tenocissimae. MIT test was applied to study the anticancer effects of liposoluble components on growth inhibition in human liver cancer line HepG-2 cells, and the chemical constituents were analyzed by gas chromatography/mass spectrometry (GC-MS).
RESULTThe liposoluble components of caulis M. tenocissimae have obvious growth inhibitory action to HepG-2 cells. Twenty-four compounds were identified and their relative contents were determined.
CONCLUSIONThe liposoluble components from caulis M. tenocissimae have antitumor activities, and its pharmacological activity is related to its chemical constituents.
