An analysis of the relationship between HBV DNA and HBeAg expression and mortality in 799 severe hepatitis patients.
- Author:
Rong-bing WANG
1
;
Gui-qin ZHOU
;
Yu-yong JIANG
;
Feng-xia SUN
;
Yun-zhong WU
;
Jing-yuan SUN
;
Pei-pei MENG
;
Si-meng NIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Child; DNA, Viral; Female; Hepatitis B Surface Antigens; Hepatitis B virus; genetics; immunology; physiology; Hepatitis B, Chronic; diagnosis; virology; Humans; Male; Middle Aged; Viral Load; Young Adult
- From: Chinese Journal of Hepatology 2006;14(9):655-657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between mortality and HBVDNA and HBeAg expression of severe hepatitis B patients.
METHODSThe mortality rates of different types of severe hepatitis patients in our hospital during the last five years were analysed. HBV DNA was detected using the fluorescence quantitative PCR method and the HBeAg expression of severe hepatitis B was studied using a microparticle method.
RESULTS(1) Hepatitis B morbidity was 83.5% in each type of severe hepatitis, and severe chronic hepatitis B morbidity was 96.77% in each type of severe chronic hepatitis. (2) The mortality rate of those with HBV DNA more than 1 x 10(5) copies/ml was 53.25% and the mortality of those with HBV DNA less than 1 x 10(5) copies/ml was 34.50% (P less than 0.01). The HBeAg expression had no influence on the death rate. (3) The death rate descended to 30.38% from 54.64% (HBV DNA more than 1 x 10(5) copies/ml) when treated with Lamivudine (P less than 0.01).
CONCLUSIONIn severe hepatitis the quantity of virus carried in the patient is one of the key factors of mortality; antivirus treatment can lower mortality.
