The efficacy of artificial liver support system treatment on hepatic failure in China: a meta-analysis.
- Author:
Yong-Feng YANG
1
;
Lin-Ling WEI
;
Ning ZHANG
;
Ping HUANG
;
Yi-Jun YANG
;
Li-Rong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Liver Failure; therapy; Liver, Artificial; Prognosis; Treatment Outcome
- From: Chinese Journal of Hepatology 2006;14(10):732-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEConducting a meta-analysis to evaluate the efficacy of artificial liver support system (ALSS) in the treatment of hepatic failure in China.
METHODSClinical trials comparing ALSS vs. routine medical treatment of hepatic failure in China were identified from computer-based literature. The pooled odds ratio and 95% confidence interval (CI) of prognostic indicators, such as survival rate and clinical improvement rate at discharge, were used to measure the magnitude of the efficacy.
RESULTSTen trials including 1030 patients were identified. The odds ratio (95% CI) of survivorship or improvement of ALSS over routine medical treatment in early, intermediate and advanced stages of hepatic failure were 3.72 (2.03-6.83), 2.79 (2.88-4.14) and 1.85 (0.96-3.56) respectively.
CONCLUSIONALSS treatment is more effective in early and intermediate stages of hepatic failure than routine medical treatment, but not in its advanced stage.
