An analysis of 276 cases of drug-induced liver damage.
- Author:
Wei-ting LU
1
;
Jun LI
;
Ning OU
;
Nian CHEN
;
Yuan LIU
;
Xue-jiang GUO
;
Rui-yun WANG
;
Xiang LU
;
Jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury, Chronic; classification; diagnosis; etiology; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Retrospective Studies; Young Adult
- From: Chinese Journal of Hepatology 2006;14(11):832-834
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEDrug-induced liver damage is a potential complication from using many drugs. The aim of our study was to analyze the etiology and clinical features of drug-induced liver damage, in order to draw more attention to this problem.
METHODSTwo hundred and seventy-six cases over a 5-year period in Jiangsu Province Hospital were retrospectively analyzed.
RESULTSA variety of drugs, including traditional Chinese medicines (26.1% of our total cases) and anticancer drugs (17%) caused liver damage. The main clinical manifestations of it were fatigue, nausea, vomiting and jaundice. In 88% of our cases the symptoms were relieved or completely disappeared, but there was still a 5.1% mortality rate.
CONCLUSIONSThe clinical features of drug-induced liver damage are of no specificity, and the mortality of it is not low. Liver function should be monitored when suspected drugs are prescribed.
