The Effects on the MSG with Phenylalanine Treatment in the Area Postrema of the Rat Medulla.
10.11637/kjpa.2000.13.2.213
- Author:
Chang Hyun LEE
1
;
Byoung Moon KO
;
Myoung Soon KIM
;
Ok Bong CHUNG
Author Information
1. Department of Anatomy, Oriental Medical School, Woosuk University, Wanju 565-701, Korea.
- Publication Type:Original Article
- Keywords:
MSG;
Phenylalanine;
AP;
TH
- MeSH:
Adult;
Animals;
Area Postrema*;
Glutamic Acid;
Humans;
Neurons;
Neurotransmitter Agents;
Phenylalanine*;
Rats*;
Rats, Sprague-Dawley;
Sodium Glutamate*
- From:Korean Journal of Physical Anthropology
2000;13(2):213-220
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Glutamate is an amino acid neurotransmitter capable of producing widespread receptor-mediated neuronal excitation. In this experiment, we examined the effect of saline, monosodium glutamate (MSG), phenylalanine and MSG-phenylalanine treatment on TH immunoreactivity in area postrema (AP) of medulla oblangata. An immunocytochemical method was used to visualize catecholaminergic neurons in the AP. Damage of TH neurons in the AP of adult Sprague-Dawley rats was induced by injection of MSG (4 mg/g bw) and was decreased by administration of MSG following phenylalanine treatment (15 mg/g bw). We conclude that phenylalanine protect from the neuroexcitotoxic effect of systemic glutamate.
