Functional Bax polymorphism associated with lung cancer susceptibility.
- Author:
Dian-ke YU
1
;
Yong-li GUO
;
Wen TAN
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; genetics; metabolism; pathology; Adult; Aged; Alleles; Asian Continental Ancestry Group; Carcinoma, Squamous Cell; genetics; metabolism; pathology; Case-Control Studies; Cell Line, Tumor; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms; genetics; metabolism; pathology; Male; Middle Aged; Odds Ratio; Polymorphism, Restriction Fragment Length; Risk Factors; Smoking; bcl-2-Associated X Protein; genetics; metabolism
- From: Chinese Journal of Oncology 2010;32(5):324-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe Bcl-2 associated X protein (Bax), belonging to the Bcl-2 family, plays a pivotal role in mitochondria-dependent apoptosis. The aims of this study are to revalidate the functional significance of Bax G(-248)A polymorphism, and investigate its association with lung cancer risk in Chinese population.
METHODSThe biological function of Bax G(-248)A was tested by luciferase assays, and its effects on lung cancer risk was determined by case-control analysis of 989 patients with lung cancer and 990 controls.
RESULTSBax -248A allele exhibited significantly higher transcriptional activity compared with G allele. The Bax-248A allele carriers yielded a significantly decreased risk of lung cancer, compared with -248G allele carriers (OR = 0.68, 95% CI = 0.48 approximately 0.90, P = 0.01). Furthermore, a significant gene-smoking interaction between Bax G(-248)A polymorphism and smoking existed among the light smokers.
CONCLUSIONBax G(-248)A polymorphism is associated with lung cancer susceptibility in Chinese population.
