Expression and significance of P311 and ITGB4BP in non-small cell lung cancer.
- Author:
Chun-lan TANG
1
;
Shun-zong YUAN
;
He-ping YANG
;
Qing-liang WANG
;
Rong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; Carcinoma, Non-Small-Cell Lung; metabolism; Carcinoma, Squamous Cell; metabolism; Eukaryotic Initiation Factors; metabolism; Humans; Immunohistochemistry; Lung Neoplasms; metabolism; Nerve Tissue Proteins; metabolism; Oncogene Proteins; metabolism; Paraffin Embedding; Signal Transduction; Tissue Array Analysis
- From: Chinese Journal of Oncology 2010;32(7):526-528
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of this study was to investigate the expression and significance of P311 and ITGB4BP in non-small cell lung cancer (NSCLC).
METHODSTissue microarrays were prepared from 80 NSCLC specimens and examined by immunohistochemistry.
RESULTSThe positive rates of P311 and ITGB4BP expression were 77.5% (62/80) and 82.5% (66/80), respectively. The double positive expression rate was 73.8% (59/80). The consistency rate was 87.5%, and there was a significant consistency between P311 and ITGB4BP expressions (Kappa = 0.611, P < 0.001).
CONCLUSIONThere may be a new signaling pathway P311-ITGB4BP in NSCLC, and it may regulate the lung cancer cell migration.
