Formation mechanism of circulating tumor cells and progress of its application in I-III stage colorectal carcinoma.
- Author:
Qing HUANG
1
;
Shu ZHENG
;
Jiao YANG
;
Ying YUAN
Author Information
1. Department of Medical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. yuanying1999@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms;
Humans;
Neoplasm Staging;
Neoplastic Cells, Circulating;
Prognosis
- From:
Chinese Journal of Gastrointestinal Surgery
2015;18(8):848-850
- CountryChina
- Language:Chinese
-
Abstract:
It has been a problem in clinical practice that high recurrence and poor survival of patients with colorectal cancer undergoing surgery. As an easy-accessible, repetitive, non-invasive "liquid biopsy" technology, circulating tumor cells(CTC) can assist us in many fields, for instance, real-time monitoring tumor status and providing information about recurrence and prognosis of colorectal cancer. In this review, generation mechanism and relevant major regulation molecules of CTC will be elucidated, and principles, superiorities and inferiorities among different detection technologies were compared. Besides, clinical application and prognostic value of CTC in stage I-III colorectal caner were discussed, and the dilemma of low detection rate of CTC will be tried to solve as well.
