Experimental study on ectopic prefabrication of vascularized mandible graft with autogenous ribs.
- Author:
Xiang WANG
1
;
Zhe SHAO
;
Han-zhong ZHANG
;
Fei ZHU
;
Hui SHEN
;
Zheng-jun SHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Transplantation; methods; Dogs; Female; Male; Mandible; surgery; Osteogenesis; Reconstructive Surgical Procedures; methods; Ribs; surgery; Tissue Engineering; methods; Transplantation, Autologous
- From: Chinese Journal of Stomatology 2012;47(9):544-546
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore a method for ectopic prefabrication of mandible with vascular pedicle.
METHODSCancellous bone blocks harvested from the dog ribs were packaged with mandible-shaped titanium mesh scaffold and implanted into latissimus dorsi of dog with thoracodorsal artery and vein through the scaffold. After 12 weeks, bone formation and vascularization were evaluated by gross inspection, histological examination and immunohistochemistry.
RESULTSVascularized mandible with thoracodorsal artery and vein were formed and histological staining and immunohistochemisty confirmed new bone formation and vascularization.
CONCLUSIONSThere is feasibility for ectopic prefabrication of vascularized mandible graft using cancellous ribs, which provides a new method for mandibular defect reconstruction. Experimental study on ectopic prefabrication of vascularized mandible graft with autogenous ribs.
