Expression of erythroblastic leukemia viral oncogene homolog 3 (ErbB-3) binding protein-1, matrix metalloproteinases, eplthelial cadherin in adenoid cystic carcinoma and correlation analysis.
- Author:
Jian SUN
1
;
You-cheng YU
;
Yi-xi LUO
;
Zhen TIAN
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; metabolism; Biomarkers, Tumor; metabolism; Cadherins; metabolism; Carcinoma, Adenoid Cystic; metabolism; pathology; secondary; Female; Follow-Up Studies; Humans; Lung Neoplasms; secondary; Lymphatic Metastasis; Male; Matrix Metalloproteinase 9; metabolism; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; RNA-Binding Proteins; metabolism; Salivary Gland Neoplasms; metabolism; pathology
- From: Chinese Journal of Stomatology 2012;47(12):711-714
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of ErbB-3 binding protein-1 (EBP-1), matrix metalloproteinase 9 (MMP-9) and E-cadherin (E-cad) in adenoid cystic carcinoma and their correlation.
METHODSImmunohistochemistry(PV6000 method) was used to detect EBP-1, MMP-9 and E-cad expression in 66 cases of adenoid cystic carcinoma tissues and matched para-cancerous normal tissues. In this study all cases were successfully followed up.
RESULTSThe positive expression rate of EBP-1 in adenoid cystic carcinoma tissues was 85%. EBP-1 expression was significantly correlated to pathological pattern and clinical stage (P < 0.05), but not to gender and age. In addition, there was a negative correlation between EBP-1 and E-cad expression, and positive correlation between EBP-1 and MMP-9.
CONCLUSIONSEBP-1 and its correlation with MMP-9 and E-cad may be used as useful indicators for clinical assessment of tumor biological behavior and prognosis in patients with adenoid cystic carcinoma.
