Effects of Potassium Aspartate and Magnesium on Ventricular Arrhythmia in Ischemia-reperfusion Rabbit Heart
10.1007/s11596-008-0506-x
- Author:
PU JUN
1
,
2
;
ZHANG CUNTAI
;
QUAN XIAOQING
;
ZHAO GUOAN
;
LV JIAGAO
;
LI BO
;
BAI RONG
;
LIU NIAN
;
RUAN YANFEI
;
HE BEN
Author Information
1. Department of Cardiology, Renji Hospital, Shanghai diaotong University School of Medicine, Shanghai 200001, China
2. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China
- Keywords:
ischemia-reperfusion;
ventricular arrhythmia;
potassium aslpartate and magnesium
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(5):517-519
- CountryChina
- Language:Chinese
-
Abstract:
Summary: The aim of this study was to determine if the potassium aspartate and magnesium (PAM) prevent reperfusion-induced ventricular arrhythmias (RIVA) in ischcmia-reperfusion (IR) rabbit heart. Thirty rabbits were randomly divided into control, ischemia and PAM groups. Arterially-perfused rabbit left ventricular preparations were made, and transmural ECG as well as action potentials from both endocardium and epicardium were simultaneously recorded in the whole process of all experiments. In control group rabbit ventricular wedge preparations were continuously perfused with Tyrode's solution, and in ischemia group and PAM groups the perfusion of Tyrode's solution was stopped for 30 min. Then the ischemia group was reperfused with Tyrode's solution and the PAM group with Tyrode's solution containing 2.42 mg/L PAM, respectively. ECG, QT interval, transmural repolarization dispersion (TDR) and action potentials from epicardium and endocardium were simultaneously recorded, and the RIVA of the wedge preparation was observed. Compared with control group, TDR and incidence of RIVA were significantly increased in ischemia group (P<0.05). The incidence of RIVA in control, ischemia and PAM group was 0/10, 9/10 and 1/10, respectively. Compared with ischemia group, TDR and incidence of RIVA were significantly reduced in PAM group (P<0.05). Potassium aspartate and magnesium significantly reduce TDR and prevent ventricular arrhythmia in ischemic rabbit heart.
