The Expression of Integrinβ1 and FAK in Pituitary Adenomas and Their Correlation with Invasiveness
10.1007/s11596-008-0518-6
- Author:
WAN FENG
1
;
SHU KAI
;
LEI TING
;
XUE DELIN
Author Information
1. Department of Neurosurgery, Tongji Hospital, Tongji Medical Collage, Huazhong University of Science and Technology, Wuhan 430030, China
- Keywords:
pituitary adenoma;
invasiveness;
integrin;
focal adhesion kinase
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(5):572-575
- CountryChina
- Language:Chinese
-
Abstract:
Summary: The expression and possible role of integrin-focal adhesion kinase signal pathway in invasive pituitary adenomas were explored. Forty-nine human pituitary adenomas were detected for the expression of integrinβ1 (INTβ1) and focal adhesion kinase (FAK) by immunohistochemistry, and their correlation with the invasiveness of pituitary adenomas as well as between themselves was analyzed. The results showed that INTβ1 was expressed in 46 cases (93.9%) and FAK in 36 cases (73.5%), respectively, and their expression levels were highly correlated with tumor invasiveness, but not with the tumor types. It was suggested that the integrin-focal adhesion kinase signal pathway plays a role in the invasiveness of pituitary adenomas.
