The Clinical Usefulness of 99mTc-Tetrofosmin Scintigraphy in the Diagnosis of Lung Neoplasmas and Mediastinal Lymphoid Node Involvement
10.1007/s11596-008-0527-5
- Author:
HUANG DAIJUAN
1
;
ZHAO FENG
;
ZHANG YONGXUE
Author Information
1. Department of Nuclear Medicine, Key Laboratory of Molecular Imaging of Hubei Province, Wuhan 430022, China
- Keywords:
lung neoplasm;
mediastinum;
lymph node;
99mTc-Tetrofosmin;
scintigraphy
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(5):608-612
- CountryChina
- Language:Chinese
-
Abstract:
Summary: In order to investigate the clinical significance of 99mTc-Tetrofosmin (TF) seintigraphy in the evaluation of lung cancer and mediastinal lymphoid node involvement, 33 patients with pulmonary neoplasmas were subjected to both 99mTc-TF scintigraphies and CT scans in one week before their operations or puncturations. All the images were judged visually and the emission images were analyzed with semi-quantitative methods in addition. The results of each group were compared. There was marked difference in target/non-target (T/N) ratio between the lung cancer group and the benign lesion group (P<0.001). Moreover, in the lung cancer group, T/N ratio in tomographies was significantly higher than that in planar images (P<0.01). The sensitivity and accuracy of semi-quantitative analysis in 99mTc-TF SPECT were significantly higher than those of CT in the diagnosis of pulmonary neoplasmas (P<0.05 and P<0.01 respectively), so was the sensitivity of 99mTc-TF SPECT vs CT in the diagnosis of mediastinai lymphoid node metastasis (P<0.05). It was also found that epidermoid squamous cell carcinomas and adenocarcinomas had a higher T/N ratio than in small cell carcinomas (P<0.05), and 2 h washout rate (WR) of adenocarcinomas was higher than that of epidermoid squamous cell carcinomas (P<0.05). In conclusion, 99mTc-TF scintigraphy showed a favorable diagnostic accuracy in appraising lung cancers and mediastinal lymph node metastases. Furthermore semi-quantitative technology can improve the accuracy, and is potential to offer some information about histological type of the cancer tissue. Therefore, 99mTc-TF scintigraphy will be a useful tool in the diagnosis and staging of lung cancer.
