Polymorphism of Apolipoprotein A5 is a Risk Factor for Cerebral Infarction in Type 2 Diabetes
- Author:
LI XUEFENG
1
,
2
;
XU YANCHENG
;
DING YAN
;
QIN CHENGMING
;
DAI ZHE
;
NIU LI
Author Information
1. Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
2. Department of Endocrinology, Taihe Hospital, Yunyang Medical College, Shiyan 442000, China
- Keywords:
apolipoprotein AS;
polymorphism;
triglyceride;
type 2 diabetes;
cerebral infarction
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(6):653-656
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the association of apolipoprotein A5 (apoAS) gene polymorphism at position -113 ITC with cerebral infarction in patients with type 2 diabetes. A total of 256 type 2 diabetic patients without cerebral infarction (T2DM), 220 type 2 diabetic patients with cerebral infarction (T2DMCI) and 340 healthy subjects were recruited from the same region (Hubei province,China). The genotype of apoA5 -1131TC was analyzed by polymerase chain reaction, followed by restriction fragment length polymorphism (PCR-RFLP). Total cholesterol, HDL cholesterol,LDL-cholesterol and trigiycerides were quantitatively detected by using standard enzymatic techniques. The results showed that the prevalence of the apoA5 -1131C allele was significantly higher in T2DMCI group than that in control group (42.7% versus 31.2%, P<0.01). The carriers of rare C allele had higher TG levels as compared with carders of common allele in the three groups (P<0.01). Logistic regression models, which were adjusted for age, gender, blood pressure, BMI, FBS, smoking,LDL-C and HDL-C, revealed that patients carrying the apoA5 -1131C allele and CC homozygotes were at high risk for T2DMCI. It was concluded that the apoA5 -ll31C allele variant is an independent genetic risk factor for T2DMCI.
