Expression of Platelet Membrane Glycoprotein Ib/IX/V Complex, a Receptor of Thrombin, in Patients with Hemorrhagic Thrombopathy
- Author:
SHEN LIN
1
;
SHEN DI
;
ZHU RUI
;
ZHU MIN
;
LU FURONG
;
QIN YOU
;
FAN HENG
Author Information
1. Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- Keywords:
platelet membrane glycoproteins;
hemorrhagic thrombopathy;
thrombin receptor;
platelet aggregation
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(6):657-659
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the role of platelet membrane glycoprotein (GP) Ib/Ⅸ/Ⅴ complex and its subunit GP Ibа in patients with hemorrhagic thrombopathy (HT), the expressions of GP lb/Ⅸ/Ⅴ complex and GP Ibа, defined as mean fluorescence intensity (MFI), were assessed by flow cytometry.The maximum aggregation of platelet was determined by turbidity method. These indicators were compared among 68 HT patients with the presenting complaint of hemorrhage, 33 well-controlled HT patients and 32 normal healthy subjects. The results showed that the MFI of GP lblIX/V complex and GP Ibct was markedly lower in HT patients with current hemorrhage than that in the healthy subjects, with difference being statistically significant (P<0.05). There was no significant difference in the expressions of GP lb/Ⅸ/Ⅴ complex and GP lbа between well-controlled HT patients and normal healthy subjects (P>0.05). It was concluded that the expression of GP Ib/Ⅸ/Ⅴ complex, the receptor of thrombin and yon Willebrand factor, was down-regulated in HT patients with current hemorrhage,which might result in the dysfunction of platelet aggregation and recurrence of HT.
