Expression and Clinical Implication of HIF-la and VEGF-C in Non-small Cell Lung Cancer
- Author:
ZUO SHUNQING
1
,
2
;
JI YANMEI
;
WANG JIANJUN
;
GUO JIALONG
Author Information
1. Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China
2. Department of Cardiothoracic Surgery
- Keywords:
lung neoplasm;
hypoxia-inducible factor- 1а;
vascular endothelial growth facor-C
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2008;28(6):674-676
- CountryChina
- Language:Chinese
-
Abstract:
To study the expression and implication of HIF-la and VEGF-C in non-small cell lung cancer (NSCLC) and its relationship with clinical pathological features of NSCLC, immunohistochemical SP was used to detect the expression of HIF-1а and VEGF-C proteins in 48 NSCLC tissues and the same para-cancerous tissues. The positive rates of HIF-1а and VEGF-C were 70.8% (34/48) and 68.8% (33/48) respectively. The expression of HIF-la protein was detected in a significantly greater proportion in NSCLC carcinoma tissues than that in para-cancerous tissues (12.5% and 16.7%,P<0.05). The positive rates of HIF-1а and VEGF-C were correlated with lymph node metastasis and TNM stage. No relationship was found between the two factors and age, sex, pathological subtypes and histological grades. The positive rates between HIF-1а and VEGF-C were correlated (P<0.05).HIF-1а and VEGF-C were over-expressed in NSCLC. They may be involved in the carcinogenesis of NSCLC, and play an important role in invasion and metastasis of NSCLC. HIF-1а and VEGF-C work synergically in the process of NSCLC.
