Epstein-Barr virus-associated Hodgkin's disease following renal transplantation.
10.3904/kjim.2006.21.1.46
- Author:
Jung Hye CHOI
1
;
Myung Ju AHN
;
Young Ha OH
;
Sang Woong HAN
;
Ho Jung KIM
;
Young Yeul LEE
;
In Soon KIM
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. jhcmd@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Post-transplant lymphoproliferative disorder;
Hodgkin's disease;
Renal transplantation
- MeSH:
Male;
Lymphoproliferative Disorders/*chemically induced/immunology/virology;
Kidney Transplantation/*adverse effects;
Immunosuppressive Agents/*adverse effects;
Humans;
Hodgkin Disease/*etiology;
*Herpesvirus 4, Human;
Epstein-Barr Virus Infections/*complications;
Adult
- From:The Korean Journal of Internal Medicine
2006;21(1):46-49
- CountryRepublic of Korea
- Language:English
-
Abstract:
Post-transplant lymphoproliferative disorders (PTLD) have been recognized as a complication of immunosuppression and occur with a reported incidence of 1 to 8% of recipients receiving solid organ transplantation. PTLD are classified into two major categories, polymorphic and monomorphic PTLD. The majority of the monomorphic PTLD cases are non-Hodgkin's lymphoma of B-cell origin. Hodgkin's disease is not part of the typical spectrum of PTLD; however, it has been rarely reported. We describe a case of Hodgkin's disease following renal transplantation. A 41-year-old man developed right cervical lymphadenopathy following renal transplantation 116 months previously for chronic renal failure of unknown origin. He had been taking cyclosporine, mycophenolate mofetil and prednisone. A lymph node biopsy revealed mixed cellularity Hodgkin's disease. Immunohistochemical staining was positive for CD30 and EBV-latent membrane protein-1. No other site of disease was identified. The immunosuppressive agents were reduced (mycophenolate mofetil was discontinued, cyclosporine dose reduced from 200 mg to 150 mg and prednisone continued at 5 mg). After 2 cycles of ABVD followed by radiation therapy (3600 cGy), he achieved complete remission.
