The difference between the positive rate of anti-HCV in the patients with severe viral hepatitis detected by the first generation or second generation enzyme linked-immunosorbent assay.
- Author:
Da-zhi ZHANG
1
;
You-rong ZHAO
;
Quan-hai ZHANG
;
Zhi-yi WANG
;
Bo QIN
;
Hua HE
;
Zhi ZHOU
;
Shu-hua GUO
;
Ding-feng ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis C Antibodies; blood; Hepatitis, Viral, Human; virology; Humans; Male; Middle Aged; Prognosis
- From: Chinese Journal of Hepatology 2004;12(5):299-300
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the positive rate of antibody to hepatitis C virus (anti-HCV) in sera of patients with severe viral hepatitis between 1984-1990 year and 1997-2003 year.
METHODSSerum anti-HCV was detected by enzyme linked-immunosorbent assay (ELISA). It was detected by the first generation (1st) ELISA (Ortho Co. USA) in 79 cases of severe viral hepatitis during 1984-1990 year, and it was detected by the second generation (2nd) ELISA (Xiamen Xingchuang Co. China) in 251 cases of severe viral hepatitis during 1997-2003 year.
RESULTSThe positive rate of serum anti-HCV was 51.9% detected by the 1st ELISA in 79 cases of severe viral hepatitis during 1984-1990 year, and it was 1.2% detected by the 2nd ELISA in 251 cases of severe hepatitis during 1997-2003 year (chi2 = 133.68, P
CONCLUSIONTo compare with the positive rate of serum antibody to hepatitis C virus in severe viral hepatitis detected by the 1st ELISA, it was lower that detected by the 2nd ELISA
