Tumor-Associated Lymphocytes Predict Response to Neoadjuvant Chemotherapy in Breast Cancer Patients.
- Author:
Hee Jin LEE
1
;
Jin Young SEO
;
Jin Hee AHN
;
Sei Hyun AHN
;
Gyungyub GONG
Author Information
- Publication Type:Original Article
- Keywords: Breast neoplasms; Lymphocytes; Neoadjuvant therapy; T-cell
- MeSH: Biopsy; Breast; Breast Neoplasms; Humans; Lymphocyte Count; Lymphocytes; Multivariate Analysis; Neoadjuvant Therapy; Polymerase Chain Reaction; Receptor, Epidermal Growth Factor; Receptor, erbB-2; Retrospective Studies; T-Lymphocytes
- From:Journal of Breast Cancer 2013;16(1):32-39
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Tumor-associated lymphocyte numbers in breast cancer have been suggested as a new independent predictor of response to neoadjuvant chemotherapy in breast cancer patients. We therefore evaluated the relationship between pathologic complete response (pCR) and tumor-associated lymphocytes in tumors of such patients. METHODS: Between 2000 and 2009, we retrospectively evaluated 175 patients with primary breast cancer treated with neoadjuvant chemotherapy, followed by definitive surgical resection. Peritumoral lymphocytic infiltration (LI) and CD3+, CD8+, and forkhead box P3 (FOXP3)+ lymphocytes were assessed in pretreatment biopsy specimens. RESULTS: Nineteen (11%) patients achieved pCR. An elevated LI, CD3+, CD8+, or FOXP3+ lymphocytic infiltration; lower clinical T stage; human epidermal growth factor receptor 2 overexpression; and herceptin-based treatment were all significantly associated with pCR. Through a multivariate analysis, LI (odds ratio [OR], 1.26; p=0.024), clinical T stage (OR, 3.06; p=0.041), and the use of a herceptin-based regimen (OR, 4.95; p=0.004) were all significant independent predictors of pCR. Significantly higher numbers of tumor-associated lymphocytes and CD3+, CD8+, and FOXP3+ T-cells were observed in the following: high-grade tumors, tumors of positive nodal status, and tumors negative for hormone receptors. CONCLUSION: Tumor-associated lymphocytes are significantly associated with pCR, suggesting that tumor-associated lymphocytes may be an important pathological factor predicting a response to neoadjuvant chemotherapy in breast cancer patients.
