Mechanism of macrophage polarization on spinal cord injury.
10.3969/j.issn.1003-0034.2018.01.017
- Author:
Bao-Ping XU
1
;
Min YAO
1
;
Xiao-Tao WANG
1
;
Long YANG
1
;
Zi-Rui TIAN
1
;
Yan-Fang PAN
1
;
Xue-Jun CUI
2
,
3
Author Information
1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
2. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
3. 13917715524@139.com.
- Publication Type:Journal Article
- Keywords:
Macrophage;
Review literature;
Spinal cord injury
- From:
China Journal of Orthopaedics and Traumatology
2018;31(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury is a serious trauma of the spinal and nervous system, local tissue destruction and microcirculation disturbance can lead to a more serious spinal cord injury and extensive necrosis of neurons. Spinal cord injury often accompany with Inflammation reaction producing a variety of cytokines and bioactive substances, result in macrophage polarization. M1 macrophages polarization are induced by IFN-γ, LPS, TNF-α and so on, it show the damage and proinflammatory effect. M2 macrophages polarization are caused by IL-4, IL-10, IL-13 and show the recovery and anti-inflammatory effect. However, clinical treatment after spinal cord injury is very limited, inhibition of proinflammatory and promotion of anti-inflammatory by regulating the M1 macrophages and M2 macrophages is a new direction for the treatment of spinal cord injury. The article will review different phenotype and function of macrophages after spinal cord injury.
