Clinical and Pathologic Features of Multifocal and Multicentric Breast Cancer in Chinese Women: A Retrospective Cohort Study.
- Author:
Mei Rong ZHOU
1
;
Zhong Hua TANG
;
Jing LI
;
Jin Hu FAN
;
Yi PANG
;
Hong Jian YANG
;
Shan ZHENG
;
Jing Qiao BAI
;
Ning LV
;
You Lin QIAO
;
Hai Zhi QI
;
Feng XU
Author Information
- Publication Type:Original Article
- Keywords: Breast; Carcinoma; Clinical pathology
- MeSH: Asian Continental Ancestry Group; Breast; Breast Neoplasms; China; Cohort Studies; Female; Humans; Incidence; Lymph Nodes; Mastectomy; Neoplasm Metastasis; Pathology, Clinical; Retrospective Studies
- From:Journal of Breast Cancer 2013;16(1):77-83
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: This study aims to analyze the clinical-pathological characteristics of multifocal and multicentric breast cancer (MMBC) in Chinese women. METHODS: Sixty-seven cases with MMBC were randomly collected and reviewed at seven hospitals in representative districts of China during 1999 to 2008. RESULTS: The incidence of MMBC in breast cancer in China was 1.75%. Compared to those with unifocal breast cancer, women with MMBC were more likely to have larger tumor size, lymph node metastasis (59.70% vs. 45.62%) and stage III to IV (46.26% vs. 21.10%). The peak age at onset of MMBC was 40 to 49 years old and has been gradually increasing during 1999 to 2008. Most of the MMBC women were treated with surgery and adjuvant therapy. CONCLUSION: In China, the incidence of MMBC in breast cancer is significantly lower than that in Western countries. Compared to unifocal breast cancer, MMBC is biologically more aggressive. Most MMBC women underwent mastectomy, instead of breast conservation surgery.
