Advance of researches on relation of Th17 cells with immuno-associatied hematologic diseases.
10.7534/j.issn.1009-2137.2014.06.050
- Author:
Li-Jing WANG
1
,
2
;
Wen QU
3
;
Zong-Hong SHAO
4
Author Information
1. Department of Hematology, Dezhou Municipal People Hospital, Dezhou 253000, Shandong Province, China
2. Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
3. Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China.
4. Department of Hematology, General Hospital, Tianjin Medical University, Tianjin 300052, China. E-mail: shaozonghong@sina.com.
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
Hematologic Diseases;
immunology;
Humans;
Interleukin-17;
Nuclear Receptor Subfamily 1, Group F, Member 3;
STAT3 Transcription Factor;
Th17 Cells;
immunology
- From:
Journal of Experimental Hematology
2014;22(6):1766-1770
- CountryChina
- Language:Chinese
-
Abstract:
Th17 cells are a newly discovered subsets of T cells. It can specifically secrete IL-17. The RORγt and STAT3 are specific transcription factors of Th17 cells. In recent researches, it has been found that Th17 cells and their proportion increased in a variety of autoimmune diseases. This article briefly reviews Th17 cells and its relationship with the occurrence and severity of several immune-related blood diseases, including aplastic anemia, autoimmune hemolytic anemia, immune thrombo-cytopenia and immune-related pancytopenia.
