Relationship between platelet specific antibodies and the onset, clinical manifestation, treatment and prognosis of ITP.
10.7534/j.issn.1009-2137.2014.06.051
- Author:
Jing-Yao MA
1
;
Zhen-Ping CHEN
1
;
Run-Hui WU
2
Author Information
1. Hematology/Oncology Center, Beijing Key Laboratory of Pediatric Hematology/Oncology, National Key Discipline of Pediatrics, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
2. Hematology/Oncology Center, Beijing Key Laboratory of Pediatric Hematology/Oncology, National Key Discipline of Pediatrics, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. E-mail:runhuiwu@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Antibodies;
immunology;
Autoimmune Diseases;
Blood Platelets;
immunology;
Humans;
Platelet Membrane Glycoproteins;
Prognosis;
Thrombocytopenia;
immunology;
therapy
- From:
Journal of Experimental Hematology
2014;22(6):1771-1774
- CountryChina
- Language:Chinese
-
Abstract:
Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease. It is considered that production of platelet auto-antibodies was one of the pathogenesis of ITP, first-line therapy including corticosteroid and immunoglobulin could reduce destruction of platelets by inhibiting production of auto-antibodies and blocking Fc-receptor of reticuloendothelial system, but some of the patients were refractory to first-line therapy and have persistent duration of the disease, having worse prognosis and developing into chronic/refractory ITP(C/RITP) . Platelet membrane glycoprotein like GPIIb/IIIa and GPIbα are the most common antigen targets, but first-line therapy was less effective to patients whose anti-GPIbα antibodies are positive. Further studies revealed that the way causing platelet destruction by anti-GPIIb/IIIa antibodies and anti-GPIbα antibodies are different: the former is mainly dependent to Fc-pathway, and the latter mainly cleared platelet by Fc-independent way. Results above indicated that detection of type of platelet auto-antibodies maybe potential to treatment and prognosis of ITP. This article summarizes relationship between platelet specific antibodies and the onset, clinical manifestation, treatment and prognosis of ITP.
