Research advances on caspase-independent cell death of K562 cells.
10.7534/j.issn.1009-2137.2014.06.053
- Author:
Fei XIN
1
;
Wu WEI
2
Author Information
1. The First Clinicial Department, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
2. Department of Hematology, Peace Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi Province,China. E-mail: weiwu88@sohu.com.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Calpain;
Caspases;
Humans;
K562 Cells;
Necrosis;
Poly(ADP-ribose) Polymerases;
bcl-2-Associated X Protein
- From:
Journal of Experimental Hematology
2014;22(6):1780-1784
- CountryChina
- Language:Chinese
-
Abstract:
Caspase independent cell death (CICD) is defined as death that ensues when a signal that normally induces apoptosis fails to activate caspases,it can be activated by PARP-1, Calpains, Bax and AIF, possessing distinctive biologic characteristic differed from apoptosis and necrosis. Recent researchs have found that the molecular mechanisms governing CICD of K562 is opposite from that of the traditional medicine killing leukemia cells, which may have the potential pharmaceutical point for new drugs. This article reviews the newly acquaintance of molecular mechanisms for CICD and recent studies concerning the induction death of K562 cells via CICD, so as to provide some reference for the research of new drug point.
