OBJECTIVEThis study was to investigate the clinical efficacy of radiotherapy and chemotherapy combined with surgical treatment for treatment of patients with primay mediastinal B-cell lymphoma.

METHODSA total of 62 patients with primay mediastinal B-cell lymphoma was selected, out of them 26 patients received radiotherapy and che-motherapy were selected as A group, other 36 patients received radiotherapy and chemotherapy combined with surgical treatment and were selected as B group. Clinical efficacy were observed and compared after treatment.

RESULTSIn A group 5 patients achieved complete remission (CR), 5 patients achieved partial remission (PR), the total remission rate of A group was 27.8%; in B grouop, 13 patients achieved complete remission (CR), 10 patients achieved PR, the total remission rate of B group was 63.9%. The average survival time of patients in B group was 57.244 months, and the average survival time of patients in A group was 55.541 months, the former was higher than latter. The 5 years survical rate of patients in A group was 57.7%, and the 5 years survival rate of patients in B group was 80.6%, the latter was significantly higher than former.

CONCLUSIONSRadiotherapy and chemotherapy combined with surgical treatment for patients with primay media-stinal B-cell lymphoma has been confirmed to be effective, and may be used in clinic.