Recent advances of studies on abnormal HOX gene in myelodysplastic syndromes and its molecular mechanisms.
10.7534/j.issn.1009-2137.2015.01.049
- Author:
Xin-Yan XIE
1
;
Zong-Hong SHAO
2
Author Information
1. Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
2. Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, China. E-mail:shaozonghong@sina.com.
- Publication Type:Journal Article
- MeSH:
DNA-Binding Proteins;
Drosophila Proteins;
Epigenesis, Genetic;
Genes, Homeobox;
Humans;
Myelodysplastic Syndromes;
Translocation, Genetic
- From:
Journal of Experimental Hematology
2015;23(1):261-265
- CountryChina
- Language:Chinese
-
Abstract:
HOX gene encodes a group of homeodomain transcription factors which are highly conserved. The caudal-type homeobox (CDX) , ten-eleven translocation (TET) genes and polycomb group (PcG) , trithorax group (TrxG) proteins act as upstream regulators of HOX genes that manipulate the targeted gene expression through genetic and epigenetic mechanisms. The abnormal expression of HOX genes and their fusions contribute to myelodysplastic syndromes (MDS) pathogenesis. Aberrant DNA methylation and NUP98-HOX translocation serve as molecular mediators of dysfunction in MDS which can be used for the evaluation of biology and therapy. This article provides an overview of recent advances of studies on HOX gene and its abnormal molecular mechanisms, as well as potential correlation with MDS.
