Establishing aplastic anemia animal model based on different pathogenesis.
10.7534/j.issn.1009-2137.2015.01.054
- Author:
Yu-Chen ZHANG
1
;
Ming-Feng ZHAO
2
Author Information
1. Department of Hematology, The First Central Clinical Medical College of Tianjing Medical University, Tianjing Municipal First Central Hespital, Tianjing 300192, China.
2. Department of Hematology, The First Central Clinical Medical College of Tianjing Medical University, Tianjing Municipal First Central Hespital, Tianjing 300192, China. E-mail:zmfzmf@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Anemia, Aplastic;
Animals;
Bone Marrow;
Disease Models, Animal;
Hematopoietic Stem Cells;
Mice;
Pancytopenia
- From:
Journal of Experimental Hematology
2015;23(1):285-289
- CountryChina
- Language:Chinese
-
Abstract:
Aplastic anemia(AA) is a disease,including congenital AA and acquired AA, characterized by an extremely hypocellular marrow and peripheral blood pancytopenia due to bone marrow failure. Congenital AA is a autosomal recessive disease due to gene mutation. Persently, acquired AA is recognized as a disease caused by destruction of hematopoietic stem cells, defective marrow microenvironment and aberrant T cellular-immunity. In order to further study its pathogenesis and to choose effective therapeutic target, it has important clinical significance to establish correspondent animal model based on different pathogenesis. This article summarizes the congenital AA amimal models including Fanc A(-/-) mouse, Fanc C(-/-) mouse, Fanc G(-/-) mouse, Fanc D1(-/-)/Fanc 2(-/-) mouse, Fanc D2(-/-) mouse and other gene deficiency mouse AA models, and the acguired AA models resulting from the hematopoietic stem cell decrease, hematopoietic microenvironment injury, immune mediation and combination of hematopoietic stem cell dicrease with immune mediation.
