Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma.
- Author:
Jin-Shui HE
1
;
Yi-Qun HUANG
2
;
Jian-Ming WENG
3
;
Li-Yun XIAO
1
;
Kai-Zhi WENG
1
;
Xu-Dong MA
4
Author Information
- Publication Type:Journal Article
- MeSH: Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lymphoma, Mantle-Cell; Signal Transduction; Wnt Signaling Pathway; beta Catenin
- From: Journal of Experimental Hematology 2015;23(2):407-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study was purposed to detect the expressions of β-catenin and P-GSK-3 β in Wnt signaling pathway of patients with mantle cell lymphoma(MCL), and investigate its relationship with the pathogenesis of MCL.
METHODSThe expression levels of β -catenin protein and P-GSK-3 protein in mantle cell lymphoma and hyperplastic lymphadenitis were detected by using anti-β-catenin, P-GSK-3β polyclonal antibody and S-P staining technique.
RESULTSThe abnormal expression of β-catenin protein(73.33%) in mantle cell lymphoma group was significantly higher than that (6.7%) in reactive lymph node hyperplasia group (P<0.05); and the positive rate of P-GSK-3 β(66.67%) in mantle cell lymphoma group was significantly higher than that (16.67%) in reactive hyperplasia of lymph node group (P<0.05). Spearman correlation analysis showed that there was obvious positive correlation (R=0.852, P<0.01).
CONCLUSIONThe abnormal high expressions of β-catenin and P-GSK-3 β protein have been confirmed to appeare in mantle cell lymphoma.
