Correlation between the Expression of microRNA 451 in Red Blood Cells and Chronic Mountain Sickness.
- Author:
Zhuo-Ya WANG
1
;
Fa-Man YANG
2
;
Ji LIU
1
;
Rong LI
1
;
Xiao-Ping LI
1
;
Ze-Hui JING
1
Author Information
- Publication Type:Journal Article
- MeSH: Altitude Sickness; Chronic Disease; Erythrocytes; Hemoglobins; Humans; MicroRNAs
- From: Journal of Experimental Hematology 2015;23(2):481-484
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the expression of microRNA-451 in red blood cells and chronic mountain sickness(CMS).
METHODSPeripheral blood samples were collected from emigrant CMS patients (28 cases), localized CMS patients (12 case), emigrant healthy people (24 case) and localized healthy people (22 case). The microRNA-451 expression in red blood cells was measured by the RT-PCR. The results combined with the clinical data of patients were analysed.
RESULTSThe expression of microRNA-451 in emigrant CMS patients was higher than that in emigrant healthy people (P<0.05); the expression of microRNA-451 in localized CMS patients was higher than that in localized healthy people (P<0.05); the microRNA-451 expression had no statistical difference between emargant and localized healthy people. The level of hemoglobin in CMS patients was positively correlated with the expression of microRNA-451 in red cells (r=0.701).
CONCLUSIONThere is a certain level of microRNA-451 in healthy people, the expression of microRNA-451 in CMS patients is significantly higher than that in healthy people. MicroRNA-451 may play an important role in the process of chronic mountain sickness.
