The associations between idiosyncratic adverse drug reactions and HLA alleles and their underlying mechanism.
- Author:
Qing WANG
1
;
Hu MEI
;
Ya-Lan ZHANG
;
Xian-Chao PAN
;
Wen TAN
;
Li CHAO
Author Information
1. College of Bioengineering, Chongqing University, Chongqing 400044, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Allopurinol;
adverse effects;
Anti-HIV Agents;
adverse effects;
Anticonvulsants;
adverse effects;
Carbamazepine;
adverse effects;
Dideoxynucleosides;
adverse effects;
Drug Hypersensitivity Syndrome;
etiology;
immunology;
Drug-Related Side Effects and Adverse Reactions;
genetics;
immunology;
Enzyme Inhibitors;
adverse effects;
Genome-Wide Association Study;
HLA Antigens;
genetics;
HLA-B Antigens;
immunology;
HLA-B15 Antigen;
immunology;
Humans;
Stevens-Johnson Syndrome;
etiology;
immunology
- From:
Acta Pharmaceutica Sinica
2013;48(6):799-808
- CountryChina
- Language:Chinese
-
Abstract:
With the advent of Twenty-First century, more and more genome-wide association studies (GWAS) showed that idiosyncratic adverse drug reactions (ADRs) were closely related with human leukocyte antigen (HLA) alleles, such as the associations of abacavir-HLA-B*5701, allopurinol-HLA-B*5801, and carbamazepine-HLA-B*1502, etc. To explore the mechanisms of these idiosyncratic drug reactions, hapten hypothesis, danger signal hypothesis, pharmacological interaction (P-I) concept and autoimmune mechanism are proposed. In this paper, recent GWAS studies on the HLA-mediated adverse drug reactions and underlying mechanism are reviewed in detail.
