Mechanism of psoriasis generation in animal models.
- Author:
Hong LI
1
;
Jin-Hong HU
Author Information
1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Aminoquinolines;
toxicity;
Amphiregulin;
Animals;
Disease Models, Animal;
EGF Family of Proteins;
genetics;
metabolism;
Humans;
Keratin-14;
genetics;
metabolism;
Keratin-5;
genetics;
metabolism;
Keratinocytes;
metabolism;
Membrane Glycoproteins;
agonists;
Mice, Transgenic;
Psoriasis;
etiology;
genetics;
metabolism;
Receptor, TIE-2;
genetics;
metabolism;
STAT3 Transcription Factor;
genetics;
metabolism;
Toll-Like Receptor 7;
agonists;
Transforming Growth Factor beta1;
genetics;
metabolism
- From:
Acta Pharmaceutica Sinica
2013;48(6):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Psoriasis is a chronic inflammatory disease related to genome-wide and surroundings, it is important to develop a suitable animal model to research psoriasis pathogenesis and evolve pharmacotherapeutics. With the development of transgenetic technology in the past few years, psoriasis virulence gene animal model become a hotspot. Research of animal model of human psoriasis genes is reviewed in the paper.
