Pharmacokinetics and tissue distribution of irinotecan hydrochloride nanoparticles.
- Author:
Fu-Ying YANG
1
;
Wen-Ping ZHANG
;
He-Li CHEN
;
Yan FU
;
Xin-Yu WANG
;
Shi-Jie WEI
;
Xiao-Ying YANG
;
Yu-Xin ZHANG
;
Hong-Wan DANG
Author Information
1. School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
administration & dosage;
blood;
pharmacokinetics;
Area Under Curve;
Camptothecin;
administration & dosage;
analogs & derivatives;
blood;
pharmacokinetics;
Chromatography, High Pressure Liquid;
Female;
Injections, Intravenous;
Male;
Mice;
Nanoparticles;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Spectrometry, Mass, Electrospray Ionization;
Tissue Distribution
- From:
Acta Pharmaceutica Sinica
2013;48(6):940-945
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the pharmacokinetics of irinotecan hydrochloride (CPT-11) in rats and the tissue distribution of CPT-11 in mice after injection of irinotecan hydrochloride nanoparticles (CPT-11 NPs) via tail veins, separately, a LC-MS/MS method was established to determine the concentration of CPT-11 in whole blood of rats and in different tissues of mice. The pharmacokinetics and tissue distribution of CPT-11 were compared after the intravenous injection of CPT-11 NPs and CPT-11 solution. Compared with CPT-11 solution, the elimination half-life of CPT-11 was prolonged from 2.28 h to 3.95 h after the intravenous injection of CPT-11 NPs, and its AUC was 1.47 times than that of CPT-11 solution. After the injection of CPT-11 NPs in mice, the concentrations of CPT-11 loaded in CPT-11 NPs were significantly higher in the whole blood, colon and lungs than those in CPT-11 solution, but lower in the spleen, liver, kidney and heart, but the least in brain. CPT-11 NPs could improve CPT-11 's AUC, and help CPT-11 to reach long circulation activity.
