Advance in the study of myocardial ischemic preconditioning and postconditioning and the clinical applications.
- Author:
Yu-Jie WU
1
;
Lian-Hua FANG
;
Guan-Hua DU
Author Information
1. Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Ischemic Postconditioning;
methods;
Ischemic Preconditioning, Myocardial;
methods;
Myocardial Infarction;
therapy;
Myocardial Ischemia;
therapy;
Myocardial Reperfusion;
adverse effects;
Myocardial Reperfusion Injury;
etiology;
prevention & control;
Receptors, G-Protein-Coupled;
agonists;
Signal Transduction
- From:
Acta Pharmaceutica Sinica
2013;48(7):965-970
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemic preconditioning and postconditioning can reduce myocardial infarct size, improve myocardial contractility, protect coronary endothelial and myocardial cell ultrastructure, as well as reduce the incidence of arrhythmias. Clinical practice has confirmed the safety and efficacy of these two methods of myocardial protection. This paper reviewed about ischemic preconditioning and postconditioning protection mechanisms in myocardial ischemia reperfusion injury and clinical research literatures in recent years, to provide a theoretical basis for finding new treatment strategies on the prevention and treatment of ischemic cardiomyopathy.
